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Search for "bacterial resistance" in Full Text gives 9 result(s) in Beilstein Journal of Organic Chemistry.
Synthesis of C6-modified mannose 1-phosphates and evaluation of derived sugar nucleotides against GDP-mannose dehydrogenase
Beilstein J. Org. Chem. 2022, 18, 1379–1384, doi:10.3762/bjoc.18.142
- of alginate overproduction contributes to the PA biofilm environment and the resultant and deleterious bacterial resistance to current antibiotic treatments [2]. Alginate production is therefore established as a major virulence factor within PA respiratory tract infections for CF sufferers, and
Chemical approaches to discover the full potential of peptide nucleic acids in biomedical applications
Beilstein J. Org. Chem. 2021, 17, 1641–1688, doi:10.3762/bjoc.17.116
α,γ-Dioxygenated amides via tandem Brook rearrangement/radical oxygenation reactions and their application to syntheses of γ-lactams
Beilstein J. Org. Chem. 2021, 17, 688–704, doi:10.3762/bjoc.17.58
- -lactams are important lead compounds, e.g., derivatives with antibacterial activity were discovered, what gains importance with respect to the increasing bacterial resistance toward traditional β-lactam antibiotics [35][36][37][38][39]. Various synthetic pathways can be applied for the construction of the
Lectins of Mycobacterium tuberculosis – rarely studied proteins
Beilstein J. Org. Chem. 2019, 15, 1–15, doi:10.3762/bjoc.15.1
- connected to colonization of the kidney [64][65]. Inhibition of carbohydrate–lectin interactions by antiadhesive drugs is an emerging anti-infective therapeutic approach, particularly in light of increasing rates of bacterial resistance to traditional antibiotics. α-D-Mannosides containing aromatic aglycons
Aminosugar-based immunomodulator lipid A: synthetic approaches
Beilstein J. Org. Chem. 2018, 14, 25–53, doi:10.3762/bjoc.14.3
Enduracididine, a rare amino acid component of peptide antibiotics: Natural products and synthesis
Beilstein J. Org. Chem. 2016, 12, 2325–2342, doi:10.3762/bjoc.12.226
- encountered to date in the development of efficient synthetic routes to facilitate drug discovery efforts inspired by the discovery of teixobactin. Keywords: amino acid; bacterial resistance; enduracididine; natural products; peptide antibiotics; Review Introduction The enduracididines The enduracididines
Effective in silico prediction of new oxazolidinone antibiotics: force field simulations of the antibiotic–ribosome complex supervised by experiment and electronic structure methods
Beilstein J. Org. Chem. 2016, 12, 415–428, doi:10.3762/bjoc.12.45
- growth of bacterial resistance. To date, only two crystal structures of linezolid bound to its ribosomal target are available: a) linezolid bound to the 50S subunit of Deinococcus radiodurans (DR) with a resolution of 3.5 Å [20] and linezolid bound to 50S of Haloarcula marismortui (HM) (resolution: 2.7 Å
De novo macrolide–glycolipid macrolactone hybrids: Synthesis, structure and antibiotic activity of carbohydrate-fused macrocycles
Beilstein J. Org. Chem. 2014, 10, 2215–2221, doi:10.3762/bjoc.10.229
- antibacterial activity [7][8]. Over time, antibiotic use has created a selection pressure that has led to bacterial resistance and a subsequent need for continuous development of new antibiotics. Despite cumbersome syntheses, erythromycin analogs continue to be used as front line antibiotics while the clinical
Synthesis of fluorinated δ-lactams via cycloisomerization of gem-difluoropropargyl amides
Beilstein J. Org. Chem. 2010, 6, No. 48, doi:10.3762/bjoc.6.48
- -difluoromethylene moiety has been reported to improve their biological activities. For example, a gem-difluoro-γ-lactam can inhibit γ-lactamase, which is responsible for bacterial resistance to γ-lactam antibiotics [2][3][4]. Additionally, α,α-difluoro lactams are precursors of some biologically active compounds [5
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